We conclude therefore that the acquired PHA presented by our patient is probably related to valganciclovir treatment. Pelger-Huët anomaly is an autosomal dominant benign condition found in 1 in 6000 individuals. Pelger-Huët anomaly is an inherited disorder in which the neutrophils become hyposegmented (i.e., the nucleus of the cells has only two lobes or no lobes at all). Once the valganciclovir treatment was completed and the drug was withdrawn, without changing the rest of the treatment, the morphological abnormalities of neutrophils were completely resolved. We assessed the haematological, infectious and iatrogenic aetiologies for an acquired PHA. We checked previous blood counts, ruling out an inherited PHA. The peripheral blood smear showed neutrophils with markedly hyposegmented nuclei or bilobed nuclei and very condensed chromatin or clumping chromatin all consistent with Pelger-Huët anomaly (PHA). Genetic studies of a family with two unusual autosomal dominant conditions: Mascular dystrophy and Pelger-Huet anomaly. The automated complete blood count revealed an abnormal white blood cells (WBC) scattergram together with WBC alert flags. This article relates the history of the Pelger-Huet anomaly as well as describes the clinical significance and diagnostic workup for the finding of a Pelger-Huet cell on peripheral smear.A follow-up blood count was performed on a 74-year-old woman diagnosed with colitis due to cytomegalovirus and under treatment with valganciclovir. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions. Making the diagnosis of the benign autosomal dominant anomaly is complicated by the morphologically similar pseudo-Pelger-Huet cell, which can signify underlying myeloid dsyplasia. In 1931, Huët, a Dutch pediatrician, identified it as an inherited disorder. Peripheral blood smear from a patient with refractory anemia with excess blasts (RAEB) shows a neutrophil with a bilobed pseudo-Pelger-Huet (Pelgeroid).
This article relates the history of the Pelger-Huet anomaly as well as describes the clinical significance and diagnostic workup for the finding of a Pelger-Huet cell on peripheral smear.ĪB - The unique historical aspects of Pelger and Huet's discovery of the Pelger-Huet cell highlight the diagnostic challenge that this morphologic finding presents to the physician. Making the diagnosis of the benign autosomal dominant anomaly is complicated by the morphologically similar pseudo-Pelger-Huet cell, which can signify underlying myeloid dsyplasia.
Goans RE, Iddins CJ, Christensen D, Wiley A, Dainiak N Health Phys 2015 Mar 108(3):303-7.
N2 - The unique historical aspects of Pelger and Huet's discovery of the Pelger-Huet cell highlight the diagnostic challenge that this morphologic finding presents to the physician. Appearance of pseudo-Pelger Huet anomaly after accidental exposure to ionizing radiation in vivo. These are the predominant type of neutrophil in patients who are heterozygous for the Pelger-Hut anomaly, which has an autosomal dominant pattern of. T1 - Historical perspective and clinical implications of the Pelger-Huet cell
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